Signal increase for dipiridamol induced stress on cardiac magnetic resonance perfusion in minipig

Methods A healthy minipig, measured 5 times using first pass DCE imaging. We sampled the arterial input function (AIF) and the tissue response function (TRF), from the mid-ventricular tissue region from anterior to inferior in the short axis view of the heart, using incoherent imaging (Steady State Incoherent, SSI, or FLASH), and coherent imaging (Steady State Coherent, SSC, or BALANCED) [1] twice, without and with dipiridamole induced stress. We compared the results from analysis methods taken from the literature, namely the Fermi function (1, ‘Fermi’), Finite Differences (2, ‘FD’), 2 Compartment Tofts (3, ‘2CTM’), Exchange (4, ‘2CXM’), Uptake (5,’2CUM’), Tofts (6,’1CTM’), Patlak (7,’Patlak’), and the Maximum Slope (8, ‘upslope’) method [2].